Luis I. Gutierrez-Rus

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

This study compares the substrate scope of a modern and ancestral family-1 glycosidase, finding the ancestral enzyme more efficient with large aglycon-containing flavonoid glycosides.

The paper identifies heme protection by polypeptides as a mechanism enhancing catalytic efficiency in ancestral proteins, suggesting it may have driven the evolution of enzymes.

The paper shows that mutations in glutamine synthetase can rescue a proline biosynthesis block by leaking a phosphorylated intermediate, enabling a new pathway and organismal adaptation.