Author

Youhua Xie

Shanghai Medical College of Fudan UniversityORCID 0000-0002-2416-7708Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Jiannan CheniD· 2 shared Ping ZhangiD· 2 shared Rong ZhangiD· 2 shared Ang LiiD· 1 shared Baolong ZhangiD· 1 shared Ben JiaiD· 1 shared Cancan CheniD· 1 shared Chao LiuiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

Jiannan ChenORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologymBioPeer-reviewedAug 20, 2025

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication

Fei Feng, Jiannan Chen, Rong Li…·Rong Zhang

This study identifies DAZAP2 as a pan-coronavirus restriction factor that inhibits viral entry and genomic replication, with physiological relevance confirmed in mouse models and human cells.

6 citationstop 5%

humanmouse

MicrobiologybioRxivPreprintJun 21, 2025

Development of a replication-defective MPXV platform for fundamental and therapeutic research

Jiannan Chen, Linyong Hu, Ning Shi…·Rong Zhang

This paper develops a replication-defective MPXV platform for antiviral research and virology studies by engineering particles that recapitulate key viral life cycle stages without requiring high-containment facilities.

2 citations

genetic perturbation / CRISPRdrug response / drug discovery

Molecular BiologyEBioMedicinePeer-reviewedFeb 1, 2022

Human Identical Sequences of SARS-CoV-2 Promote Clinical Progression of COVID-19 by Upregulating Hyaluronan via NamiRNA-Enhancer Network

Wei Li, Shuai Yang, Peng Xu…·Wenqiang Yu

This paper identifies human identical sequences in SARS-CoV-2 that upregulate hyaluronan via a miRNA-enhancer network, contributing to cytokine storm and ARDS in COVID-19, suggesting potential therapeutic strategies.

46 citationstop 3%

humanstatistical model