Rong Zhang

This study identifies UHRF1 as a host factor that restricts HCoV-229E infection by epigenetically silencing its receptor APN, with age-related UHRF1 decline linked to increased viral susceptibility.

This paper identifies and characterizes C10, a potent SARS-CoV-2 NSP14 inhibitor with antiviral activity and host transcriptome modulation effects.

This study identifies DAZAP2 as a pan-coronavirus restriction factor that inhibits viral entry and genomic replication, with physiological relevance confirmed in mouse models and human cells.

This paper develops a replication-defective MPXV platform for antiviral research and virology studies by engineering particles that recapitulate key viral life cycle stages without requiring high-containment facilities.

This study identifies GPI biosynthesis as a conserved host restriction factor against coronaviruses, with LY6E as a key antiviral effector.