Select DYRK1A Inhibitors Enhance Both Proliferation and Differentiation in Human Pancreatic Beta Cells
Peng Wang, Olivia Wood, Lauryn Choleva, Hongtao Liu, Esra Karaköse, Luca Lambertini, Aidan Pillard, Vickie Wu, Adolfo Garcı́a-Ocaña, Donald K. Scott, Kunal Kumar, Robert J. DeVita, Andrew Francis Stewart
This study identifies harmine, 2-2c, and 5-IT as DYRK1A inhibitors that enhance both beta cell proliferation and differentiation, while others fail to induce differentiation.
bioRxiv · May 17, 2024 · PreprintMolecular Biology