Author
Icahn School of Medicine at Mount SinaiORCID 0000-0002-1184-4837Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Peng Wang, Kunal Kumar, Luca Lambertini…·Andrew F. Stewart
This paper shows harmine, a DYRK1A inhibitor, selectively promotes human beta cell differentiation and function via PKA activation, distinct from other DYRK1A inhibitors.
Peng Wang, Olivia Wood, Lauryn Choleva…·Andrew Francis Stewart
This study identifies harmine, 2-2c, and 5-IT as DYRK1A inhibitors that enhance both beta cell proliferation and differentiation, while others fail to induce differentiation.
Ruoxi Wu, Susmita Khamrui, Tetyana Dodatko…·Sander M. Houten
The paper characterizes the human SUGCT enzyme, determines its structure, and identifies inhibitors that may lead to new treatments for glutaric aciduria type 1.