Esra Karaköse

Epigenetic Profiling of Human Insulinomas Reveals AP-1 Family as Critical Regulators of Beta Cell Maturation

The paper identifies AP-1 family transcription factors as critical regulators of beta cell maturation by analyzing epigenomic and transcriptomic profiles of human insulinomas.

Harmine Selectively Drives Human Beta Cell Differentiation and Function Via Protein Kinase A Pathways

This paper shows harmine, a DYRK1A inhibitor, selectively promotes human beta cell differentiation and function via PKA activation, distinct from other DYRK1A inhibitors.

Select DYRK1A Inhibitors Enhance Both Proliferation and Differentiation in Human Pancreatic Beta Cells

This study identifies harmine, 2-2c, and 5-IT as DYRK1A inhibitors that enhance both beta cell proliferation and differentiation, while others fail to induce differentiation.