Ilaria Rebay

The Abelson kinase and the Nedd4-family E3 ligases co-regulate Notch trafficking to limit signaling

This study shows how Abelson kinase and Nedd4-family E3 ligases regulate Notch trafficking through phosphorylation and ubiquitination to control signaling output.

Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila

The paper shows that a two-fold change in the Pnt/Yan transcription factor ratio drives photoreceptor fate transitions in Drosophila eye progenitor cells, revealing a mechanism for ultrasensitivity.

Orthogonal coupling of a 3D cytoskeletal scaffold coordinates cell morphogenesis and maintains tissue organization in the Drosophila pupal retina

The paper investigates how cytoskeletal remodeling coordinates cell morphogenesis and tissue organization in the Drosophila pupal retina through intercellular feedback mechanisms.

An unexpected bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition

The paper identifies a bifurcation in the Pnt effector network in Drosophila retina that contributes to cell fate specificity and robustness during photoreceptor specification.

The Abelson tyrosine kinase and the Nedd4-family ubiquitin ligase Suppressor of Deltex converge at the Notch PPxY motif to regulate endosomal trafficking and signaling

Cooperative recruitment of Yan to paired high affinity ETS sites organizes repression to confer specificity and robustness to cardiac cell fate specification

The paper shows that Yan's preference for high affinity ETS sites and their pairing ensures specific and robust repression during cardiac cell fate specification.