This study shows how Abelson kinase and Nedd4-family E3 ligases regulate Notch trafficking through phosphorylation and ubiquitination to control signaling output.

2 citations

experimental assay

Developmental BiologyDevelopmentPeer-reviewedMar 21, 2023

Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila

Sebastian M. Bernasek, Suzy S. J. Hur, Nicolás Peláez…·Richard W. Carthew

The paper shows that a two-fold change in the Pnt/Yan transcription factor ratio drives photoreceptor fate transitions in Drosophila eye progenitor cells, revealing a mechanism for ultrasensitivity.

5 citations

Drosophilastatistical model

Developmental BiologybioRxivPreprintMar 6, 2023

Orthogonal coupling of a 3D cytoskeletal scaffold coordinates cell morphogenesis and maintains tissue organization in the Drosophila pupal retina

Xiao‐Jian Sun, Jacob R. Decker, Nicelio Sanchez‐Luege, Ilaria Rebay

The paper investigates how cytoskeletal remodeling coordinates cell morphogenesis and tissue organization in the Drosophila pupal retina through intercellular feedback mechanisms.

DOI 10.1101/2023.03.06.531386

Drosophilaexperimental assay

Developmental BiologybioRxivPreprintOct 20, 2020

The Abelson tyrosine kinase and the Nedd4-family ubiquitin ligase Suppressor of Deltex converge at the Notch PPxY motif to regulate endosomal trafficking and signaling

Nicelio Sanchez‐Luege, Julio Miranda-Alban, Xiao‐Jian Sun…·Ilaria Rebay

DOI 10.1101/2020.10.20.347468

experimental assay