SARS-CoV-2 ORF8 modulates the upper respiratory tract inflammatory response to facilitate transmission
Grace O. Ciabattoni, Stacey Bartlett, Marisa E. McGrath, Matthew B. Frieman, Meike Dittmann, Mila Brum Ortigoza
This study shows that SARS-CoV-2 ORF8 enhances upper respiratory tract inflammation and virus shedding, promoting transmission by modulating type-I interferon signaling.
bioRxiv · Aug 11, 2026 · PreprintMicrobiology