Stephen T. Yeung

Inhibiting Glycan Degradation Prevents HIV-Induced Inflammaging and Cognitive Impairment

This study shows that inhibiting glycan degradation prevents HIV-induced inflammation, aging, and cognitive impairment in animal models and human cohorts.

Immune pathways that regulate neutrophil activation and replenishment prevent persistent pneumococcal colonization

This study identifies IL-17RA and IL-1R signaling pathways that prevent persistent pneumococcal colonization by regulating neutrophil replenishment and activation in mice.

IFNγ-Driven Inflammatory Responses in the Nasal Mucosa Drive Influenza Virus Shedding and Transmission

This study shows that IFNγ-driven inflammation in the nasal mucosa increases influenza virus shedding and transmission, linking infectiousness to host immune responses rather than viral replication alone.

Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation

This study identifies nerve-associated macrophages (NAMs) as regulators of adipose homeostasis and inflammation during aging, showing their depletion accelerates inflammaging and impairs lipolysis.

Vagal TRPV1+ sensory neurons regulate myeloid cell dynamics and protect against influenza virus infection

This study shows TRPV1+ sensory neurons protect against influenza by modulating myeloid cell responses and reducing immunopathology.

Transient lung eosinophilia during breakthrough influenza infection in vaccinated mice is associated with protective and balanced Type 1/2 immune responses.

This study shows that vaccinated mice experiencing breakthrough influenza infection have transient lung eosinophilia linked to balanced Type 1/2 immune responses without severe pathology.

Mouse genomic rewriting and tailoring: synthetic Trp53 and humanized ACE2

This paper introduces mSwAP-In, a method for efficient genome rewriting in mouse embryonic stem cells, demonstrating its use for Trp53 and ACE2 locus modifications to create more accurate disease models.