Benjamin Robert tenOever

This study shows that IFNγ-driven inflammation in the nasal mucosa increases influenza virus shedding and transmission, linking infectiousness to host immune responses rather than viral replication alone.

This paper presents a computational drug repurposing framework that identifies FDA-approved drugs for COVID-19 by integrating genetic expression data and EMR data, finding four compounds with protective effects in validation.

This paper introduces mSwAP-In, a method for efficient genome rewriting in mouse embryonic stem cells, demonstrating its use for Trp53 and ACE2 locus modifications to create more accurate disease models.

This study identifies SARS-CoV-2-induced transcriptomic changes in sensory tissues that correlate with time-dependent hypersensitivity in hamsters.

The paper identifies IL10RB as a key regulator of COVID-19 host susceptibility and severity through integrative analysis of genetic and transcriptomic data, and validates potential drug repositioning candidates.

This study investigates how SARS-CoV-2 infection affects mitochondrial gene expression in different tissues and disease stages, finding targeted inhibition in some organs and upregulation in others.

The paper identifies SLC6A20 and CXCR6 as putative causal genes for the 3p21.31 GWAS signal in COVID-19 using an integrative approach combining CRISPR screens and eQTL data.

This study reconstructs ancient viral genomes from Colonial-era remains in Mexico, linking their origin to Africa via the transatlantic slave trade.

The paper shows the D614G mutation in SARS-CoV-2 Spike protein increases infection efficiency in multiple human cell lines by enhancing proteolytic resistance.

This study identifies nuclear architecture disruption as a mechanism underlying SARS-CoV-2 induced anosmia by analyzing human and hamster olfactory tissues.

The paper examines cell-type-specific expression of RAS components across 141 cell types using scRNA-seq and links ACE2 expression to SARS-CoV-2 infection mechanisms.