Minako Suzuki

The paper reconstitutes planar cell polarity in cultured epithelial cells by integrating Wnt signaling, tissue tension, and Prickle3 overexpression, showing their roles in polarity axis establishment and direction.

This study shows that Wnt11 and core PCP components interact reciprocally to establish cell polarity in Xenopus embryos without relying on Wnt gradients.

The paper shows that heparan sulfate proteoglycans (HSPGs) are dynamically polarized during vertebrate neural tube formation, interacting with Wnt11 and core PCP components to establish planar cell polarity.