Tomoe Kobayashi

Characterization of a maintainable human myeloid model of VEXAS syndrome with enhanced TNF-induced cell death and DAMP release

This study creates a human myeloid cell model of VEXAS syndrome with UBA1 mutations, showing increased TNF-induced cell death and DAMP release.

Cellular fitness is determined by ribosomal protein S12-mediated release of a truncated Xrp1

The paper identifies a post-transcriptional mechanism where ribosomal protein S12 regulates Xrp1 expression through alternative splicing, leading to cell death in unfit cells.

Emergence of cell polarity by reciprocal interactions between Wnt and core PCP components

This study shows that Wnt11 and core PCP components interact reciprocally to establish cell polarity in Xenopus embryos without relying on Wnt gradients.

Development of a sandwich ELISA for the detection of bovine A1 beta-casein

This paper develops a sandwich ELISA to detect A1 beta-casein in A2 milk, showing it can identify contamination at 1% A1 spike in a herd of A2A2 cows.

Dynamic polarization of heparan sulfate proteoglycans is involved in planar cell polarity and localization of endogenous Wnt11 during vertebrate neural tube formation.

The paper shows that heparan sulfate proteoglycans (HSPGs) are dynamically polarized during vertebrate neural tube formation, interacting with Wnt11 and core PCP components to establish planar cell polarity.