Molecular BiologyJournal of Medicinal ChemistryPeer-reviewed
Dissecting structural and functional determinants of microtubule stabilization through guided chemical modulation
Francesca Bonato, Rebeca París-Ogáyar, Ahmed Soliman…·María A. Oliva
The paper designs and characterizes PTX analogues to separate MT stabilization from structural changes, showing that compound 1b preserves native MT structure and physiological Tau dynamics.
DOI 10.1021/acs.jmedchem.6c01666