Author

Francesca Bonato

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-0579-2874Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Daniel Lucena‐AgelliD· 2 shared Denisa OndruskovaiD· 2 shared Federico GagoiD· 2 shared José Fernando DíaziD· 2 shared Juan Estévez‐GallegoiD· 2 shared Marcus BrauniD· 2 shared María A. OlivaiD· 2 shared Óscar FernándeziD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Daniel Lucena‐AgellORCID

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2 papers

Recent·Most cited

Dissecting structural and functional determinants of microtubule stabilization through guided chemical modulation

Francesca Bonato, Rebeca París-Ogáyar, Ahmed Soliman, Óscar Fernández, Beatriz Álvarez‐Bernad, Juan Francisco Giménez-Abián, Daniel Lucena‐Agell, Rafael Hortigüela, Lisha Singh, Juan Estévez‐Gallego, Wei‐Shuo Fang, Denisa Ondruskova, Valle Palomo, Federico Gago, Marcus Braun, , María A. Oliva

The paper designs and characterizes PTX analogues to separate MT stabilization from structural changes, showing that compound 1b preserves native MT structure and physiological Tau dynamics.

Journal of Medicinal Chemistry · Jul 30, 2026Peer-reviewedMolecular Biology

An atlas of microtubule lattice parameters regulated through ligand binding to the microtubule stabilizing sites.

Daniel Lucena‐Agell, Óscar Fernández, Rebeca París-Ogáyar, Juan Estévez‐Gallego, Denisa Ondruskova, Beatriz Álvarez-Bernad, Francesca Bonato, Jaime Larraga, D. Ortiz de Elguea, Gregorio Javier Cano, Marvin Scheers, Hiroshi Imai, Toshiki Yagi, Hiroyuki Iwamoto, Juan Carlos Martínez-Guil, , José Fernando Díaz

This paper investigates how microtubule-stabilizing ligands alter lattice conformation and function, showing they stabilize distinct longitudinal states that affect nucleotide hydrolysis and motor protein interactions.

Proceedings of the National Academy of Sciences · Jun 16, 2026Peer-reviewedBiophysics