Denisa Ondruskova

The paper designs and characterizes PTX analogues to separate MT stabilization from structural changes, showing that compound 1b preserves native MT structure and physiological Tau dynamics.

This paper investigates how microtubule-stabilizing ligands alter lattice conformation and function, showing they stabilize distinct longitudinal states that affect nucleotide hydrolysis and motor protein interactions.

The paper shows that co-polymerization of different tubulin isotypes creates sectioned microtubules that differentially bind MAPs like TPPP1 and OPTN.