Daniele Passarella

Dissecting structural and functional determinants of microtubule stabilization through guided chemical modulation

The paper designs and characterizes PTX analogues to separate MT stabilization from structural changes, showing that compound 1b preserves native MT structure and physiological Tau dynamics.

Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras

This study designs and tests PROTACs targeting β-tubulin, showing two compounds effectively degrade tubulin in cells.

Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule regulation

The paper uses live-cell imaging to identify a drug candidate that restores microtubule regulation by targeting tau aggregation and phosphorylation in a tauopathy model.