Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2
Nishit Goradia, Stefan Werner, Edukondalu Mullapudi, Sarah Greimeier, Lina Bergmann, András Láng, Haydyn D. T. Mertens, Aleksandra Węglarz, Simon Sander, Grzegorz Chojnowski, Harriet Wikman, Oliver Ohlenschläger, Gunhild v. Amsberg, Klaus Pantel, Matthias Wilmanns
The paper shows RAI2 induces CtBP polymerization, leading to loss of corepressor function in cancer cells and reduced RAI2 in advanced prostate cancer.
Nature Communications · Jun 19, 2024Peer-reviewedMolecular Biology