Edukondalu Mullapudi

This study shows that single-site DNA methylation activates Retron-Sen2 by enabling RcaT tetramerisation, leading to retron disassembly and toxicity.

This study shows that the flexibility of the central pore in the ESX-5 type VII secretion system is essential for efficient substrate translocation, as rigidification of key residues impairs secretion.

The paper develops a deep mutational scanning framework to map variants to molecular functions in RBM20, identifying functional hotspots and therapeutic strategies for dilated cardiomyopathy.

The paper reveals the asymmetric architecture of a mycobacterial ACCase complex with distinct short-chain and long-chain acyl-CoA carboxyl transferase activities.

This study reveals the structural and functional role of Pex8 in peroxisomal cargo translocation by interacting with Pex5, facilitating receptor recycling.

The paper shows RAI2 induces CtBP polymerization, leading to loss of corepressor function in cancer cells and reduced RAI2 in advanced prostate cancer.