Matthias Wilmanns

Single-site DNA methylation activates retron defence by enabling effector tetramerisation

This study shows that single-site DNA methylation activates Retron-Sen2 by enabling RcaT tetramerisation, leading to retron disassembly and toxicity.

Intrinsic flexibility of Type VII secretion central pore is required for substrate translocation

This study shows that the flexibility of the central pore in the ESX-5 type VII secretion system is essential for efficient substrate translocation, as rigidification of key residues impairs secretion.

Multimodal phenotyping defines variant-to-function maps for RBM20 in dilated cardiomyopathy

The paper develops a deep mutational scanning framework to map variants to molecular functions in RBM20, identifying functional hotspots and therapeutic strategies for dilated cardiomyopathy.

Architecture of an asymmetric mycobacterial short chain/long chain acyl-CoA carboxylase

The paper reveals the asymmetric architecture of a mycobacterial ACCase complex with distinct short-chain and long-chain acyl-CoA carboxyl transferase activities.

Structure of Pex8 in complex with peroxisomal receptor Pex5 reveals its essential role in peroxisomal cargo translocation

This study reveals the structural and functional role of Pex8 in peroxisomal cargo translocation by interacting with Pex5, facilitating receptor recycling.

Activity regulation of a glutamine amidotransferase bienzyme complex by substrate-induced subunit interface expansion

The paper investigates how substrate-induced subunit interface expansion regulates catalysis in a glutamine amidotransferase complex, revealing a mechanism for synchronized activity across the enzyme family.

Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2

The paper shows RAI2 induces CtBP polymerization, leading to loss of corepressor function in cancer cells and reduced RAI2 in advanced prostate cancer.

Asymmetric horseshoe-like assembly of peroxisomal Yeast Oxalyl-CoA synthetase

The paper determines the structural assembly of yeast Oxalyl-CoA synthetase, revealing asymmetric hexameric arrangements and identifying key self-association interfaces.

Structural basis of p62/SQSTM1 helical filaments, their presence in p62 bodies and role in cargo recognition in the cell

This study determines the structural basis of p62/SQSTM1 PB1 domain filaments, their role in phase-separated p62 bodies, and their importance in cargo recognition and lysosomal targeting.