Klaus Pantel

This study uses ctDNA profiling to predict tissue-of-origin and identify actionable biomarkers in cancer of unknown primary, providing diagnostic and therapeutic insights in most cases.

This paper provides methodological guidance for integrating liquid biopsy features using AI, emphasizing data preprocessing, feature selection, and model validation.

The paper identifies altered CD4 T-cell immune profiles in NSCLC patients with oligo-metastatic brain disease compared to poly-metastatic disease and healthy controls.

This study shows that red blood cells from cancer patients enhance tumour cell invasiveness and metastatic potential through gene and protein changes, suggesting PAK4 as a therapeutic target.

The paper shows RAI2 induces CtBP polymerization, leading to loss of corepressor function in cancer cells and reduced RAI2 in advanced prostate cancer.

This paper identifies TAM receptors MERTK and TYRO3 in osteoclasts regulating bone homeostasis through RHOA-COFILIN-MYOSIN II signaling, with MERTK promoting osteoclast formation and TYRO3 inhibiting it.