Anie Philip

A CD109-SMURF2 Axis Diverts EGFR from Degradation to Sustain Oncogenic Signaling and Promote Squamous Cell Carcinoma Invasion and Stemness

This study identifies the CD109-SMURF2 axis as a mechanism that prevents EGFR degradation, sustaining oncogenic signaling and promoting SCC invasion and stemness.

Loss of CD109 Amplifies NF-κB Signaling and Inflammatory Reprogramming in Dermal Fibroblasts

This study shows that loss of CD109 enhances NF-κB signaling and inflammatory reprogramming in dermal fibroblasts, contributing to skin inflammation in systemic sclerosis.

Rewiring of EGFR oncogenic program by opposing actions of membrane versus soluble CD109 in HNSCC

This study shows that soluble CD109 inhibits EGFR signaling and cancer stemness in HNSCC by blocking mCD109-EGFR interactions and promoting EGFR degradation.

Epidermal CD109 Overexpression Limits Cutaneous Inflammatory Signaling

This study shows that overexpressing CD109 in epidermis reduces inflammatory responses by limiting immune cell recruitment and suppressing inflammatory signaling pathways.