NMDA receptor hypofunction on GABAergic interneurons results in input-specific Excitatory/Inhibitory imbalance in pyramidal neurons of medial prefrontal cortex.
Carlos A. Pretell Annan, Juan Emilio Belforte, Diego E. Pafundo
This study shows that NMDA receptor hypofunction in GABAergic interneurons causes pathway-specific excitatory/inhibitory imbalance in mPFC pyramidal neurons, affecting only ventral hippocampal inputs.
bioRxiv · Aug 19, 2026 · PreprintNeuroscience