David A. Lewis

PAQu estimates protein isoform abundances using multiomic data, outperforming existing methods and revealing increased C4A isoform levels in schizophrenia.

This study identifies progressive molecular differences in depression across clinical stages using RNA-seq data, revealing shared and distinct pathways and cell-type-specific changes associated with symptom dimensions and therapeutic targets.

This study identifies tissue-specific molecular signatures and convergent pathways in suicide by analyzing transcriptomic data from blood and brain tissues.

This study examines RNA expression in thalamic nuclei of OCD patients and controls, finding minimal differential expression despite previous findings in other brain regions.

The paper compares distractibility between marmosets and macaques in cognitive tasks and links it to dopamine D1 receptor expression in prefrontal parvalbumin neurons.

The paper develops a platform combining machine learning and multiplexed in situ screening to identify enhancers with cell-type and behavioral specificity for neural circuit engineering.

This paper uses volume electron microscopy to analyze 3D synaptic structures in postmortem human prefrontal cortex, showing consistency with experimental models and revealing complex synaptic features.

The paper identifies circRNA hypomethylation in the human amygdala linked to FKBP5 in alcohol use disorder, with replication in an animal model.

This paper introduces SISTM to map 3D synaptic nanoarchitecture in brain tissue across species using cryo-ET and STA, revealing conserved structural features in human postmortem tissue.

The paper shows aging reduces mRNA expression of dopamine and glutamate markers in midbrain neurons of mice and humans, but not protein levels or cell numbers.

This study reduces neuronal excitability in monkey prefrontal cortex using Kir2.1 channels and finds decreased excitatory synaptic strength without affecting inhibitory inputs.

The paper examines single neuron diversity in primate visual cortical areas V1 and LPFC, finding differences in morphology, electrophysiology, and intrinsic bursting that may underlie functional specialization.

The paper links chronic pain genetic variants to dorsal horn neuron subtypes using multi-species single-cell and spatial transcriptomic analyses.

This study shows that kynurenic acid (KYNA) and its enzyme KAT II expand in primate dlPFC, impairing cognitive functions by affecting NMDA and nic-7Rs, and suggests targeting KYNA as a therapeutic approach for neuroinflammatory disorders.

The paper identifies cell-type specific chromatin accessibility QTLs and their functional impact on brain disease risk.

The paper uses single nuclei RNA-sequencing to identify striatal cell types in humans and rhesus macaques and finds molecular changes linked to opioid use disorder.

This study examines CB1R levels in excitatory and inhibitory boutons in schizophrenia patients, finding increased CB1R in excitatory boutons and decreased in inhibitory ones, suggesting altered neurotransmission balance.

The paper identifies synaptic protein alterations and circadian rhythm disruptions in brain regions associated with opioid use disorder using proteomics.

The paper introduces a cryo-FIB workflow to image brain tissue via in situ cryo-EM, enabling visualization of subcellular structures in fresh, unfixed mouse and postmortem human brain tissue.

The paper identifies population-level variation in enhancer expression in the human brain and links enhancer eQTL to schizophrenia heritability.

The paper investigates why gamma oscillations have higher frequency in primate prefrontal cortex compared to parietal cortex, finding no differences in GABAAR inhibition but suggesting stronger excitatory drive in prefrontal neurons.

The paper investigates molecular rhythm alterations in the prefrontal cortex and nucleus accumbens of individuals with opioid use disorder, finding distinct rhythmic transcript patterns and associations with sleep and neurotransmitter systems.

The paper identifies acetylated chromatin domains associated with dysfunction in schizophrenia and bipolar disorder by analyzing histone modifications in prefrontal cortex samples.

The paper integrates transcriptomic data with in-silico analyses to identify cellular, molecular, and causal pathways in trait and state depression.

The paper shows that mitochondrial proteostasis genes in a neurodevelopmental syndrome locus are essential for synapse function and behavior in Drosophila.

This study identifies transcriptional changes in opioid use disorder brains, linking neuroinflammation and synaptic remodeling through RNA-seq and integrative analyses.

This study investigates the role of Kcns3 in PV neuron function using computational models and electrophysiology in Kcns3-deficient mice, finding disruptions in firing patterns and gamma oscillations.

The paper identifies VGLUT expression as a sex-dependent mediator of age-related dopamine neuron vulnerability in Parkinson's disease.

The paper identifies differentially expressed transcripts in OCD patients' striatum and OFC, showing enrichment for synapse-associated genes and changes in cell type fractions.

This study identifies MAP2 phosphorylation changes in schizophrenia, linking them to neuronal structure and synaptic function impairments through phosphoproteomics and transgenic mouse models.