Author

William S. Hart

University of VirginiaORCID 0000-0002-2555-9404Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Damien ThéveniniD· 2 shared Matthew J. LazzaraiD· 2 shared Rachel L. Fetter· 2 shared Sophie Rizzo· 2 shared Bokai SongiD· 1 shared Forest M. WhiteiD· 1 shared Katie KnightiD· 1 shared Sung Hyun LeeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 24 mutual co-author links

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2 shared papersSystems Biology

Damien ThéveninORCID

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2 papers

Recent·Most cited

Systems modeling identifies phenotype-determining signaling pathways controlled by phosphatase PTPRJ in diverse receptor tyrosine kinase activation settings

William S. Hart, Katie Knight, Sophie Rizzo, Sung Hyun Lee, Rachel L. Fetter, Damien Thévenin, Matthew J. Lazzara

The paper models PTPRJ's role in regulating cell phenotypes through RTK signaling pathways in cancer cells, identifying context-dependent mechanisms.

bioRxiv · May 4, 2026 · PreprintSystems Biology

PTPRJ-Targeting Peptide Agonist Induces Broad Cellular Signaling Perturbations and DNA Damage in Lung Cancer Cells

Sophie Rizzo, William S. Hart, Rachel L. Fetter, Bokai Song, Forest M. White, Matthew J. Lazzara, Damien Thévenin

This study evaluates a PTPRJ-targeting peptide agonist's effects on lung cancer cells, revealing broad signaling changes, DNA damage, and growth inhibition.

bioRxiv · Nov 17, 2025 · PreprintBiochemistry