Author

Sophie Rizzo

Lehigh University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Damien ThéveniniD· 3 shared Matthew J. LazzaraiD· 2 shared Rachel L. Fetter· 2 shared William S. HartiD· 2 shared Alexandre Bergeron· 1 shared Avinash D. LondheiD· 1 shared Benoît BoiviniD· 1 shared Bokai SongiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Damien ThéveninORCID

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3 papers

Recent·Most cited

Systems modeling identifies phenotype-determining signaling pathways controlled by phosphatase PTPRJ in diverse receptor tyrosine kinase activation settings

William S. Hart, Katie Knight, Sophie Rizzo, Sung Hyun Lee, Rachel L. Fetter, Damien Thévenin, Matthew J. Lazzara

The paper models PTPRJ's role in regulating cell phenotypes through RTK signaling pathways in cancer cells, identifying context-dependent mechanisms.

bioRxiv · May 4, 2026 · PreprintSystems Biology

Rational design of a protein-protein interaction inhibitor that activates Protein Tyrosine Phosphatase 1B.

Avinash D. Londhe, Sophie Rizzo, Syed Husain Mustafa Rizvi, Alexandre Bergeron, Reddy Sudheer Sagabala, Nilesh K. Banavali, Damien Thévenin, Benoît Boivin

This paper designs a PPI inhibitor peptide that activates PTP1B by disrupting its interaction with the 14-3-3ζ complex, leading to reduced EGFR phosphorylation and cancer cell viability.

bioRxiv · Mar 21, 2026 · PreprintBiochemistry

PTPRJ-Targeting Peptide Agonist Induces Broad Cellular Signaling Perturbations and DNA Damage in Lung Cancer Cells

Sophie Rizzo, William S. Hart, Rachel L. Fetter, Bokai Song, Forest M. White, Matthew J. Lazzara, Damien Thévenin

This study evaluates a PTPRJ-targeting peptide agonist's effects on lung cancer cells, revealing broad signaling changes, DNA damage, and growth inhibition.

bioRxiv · Nov 17, 2025 · PreprintBiochemistry