Xiaosong Gu

The paper introduces ALICE, a platform that uses function-guided in silico evolution to design AAV capsids with tailored properties, demonstrating improved targeting and tropism in mice.

This study identifies ALKBH5 as an RNA m6A demethylase that inhibits axon regeneration in both peripheral and central nervous systems by modulating lipid metabolism.

This study uses scRNA-seq to identify immune cell-driven angiogenesis mechanisms in rat spinal cord injury.

This study develops a noninvasive nanodrug delivery system for spinal cord injury that targets both ROS scavenging and neuronal excitability, leading to significant functional recovery in rats.

This study uses spatial transcriptomics to map gene expression and intercellular interactions in glial scars after spinal cord injury, revealing spatial heterogeneity and lineage trajectories.

The paper identifies neuronal stem cells in adult rat sciatic nerve that generate sensory neurons, proposing a model of adult neurogenesis in the PNS and suggesting potential therapeutic applications.