Author

Binjie Guo

First Affiliated Hospital Zhejiang University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:contrastive learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein sequence· 1

Frequent Co-Authors

Hanyu Zheng· 3 shared Xuhua WangiD· 3 shared Haohan Jiang· 2 shared Xiaosong GuiD· 2 shared Yanming Zuo· 2 shared Aisheng Mo· 1 shared Ao FangiD· 1 shared Bin YuiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersBioengineering

Hanyu Zheng

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Mapping AAV capsid sequences to functions through function-guided in silico evolution

Binjie Guo, Hanyu Zheng, Xurong Lin, Haohan Jiang, Aisheng Mo, Hongyan Wei, Ru Zhang, Yubin Yuan, Yile Wu, Hengguang Li, Yunshuo Zhang, Zhuoyuan Song, Xuebin Ni, Yan Huang, Bin Yu, , Xuhua Wang

The paper introduces ALICE, a platform that uses function-guided in silico evolution to design AAV capsids with tailored properties, demonstrating improved targeting and tropism in mice.

Cell Press Blue · May 1, 2026Peer-reviewedBioengineering

Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy

Binjie Guo, Hanyu Zheng, Haohan Jiang, Xiaodan Li, Naiyu Guan, Yanming Zuo, Yicheng Zhang, Hengfu Yang, Xuhua Wang

This paper introduces FeatNN, a coevolutionary strategy for predicting compound-protein binding affinity by jointly representing protein sequence and structure information, achieving higher accuracy than existing methods.

Briefings in Bioinformatics · Dec 26, 2022Peer-reviewedBioinformatics

Improving functional recovery after severe spinal cord injury by a noninvasive dual functional approach of neuroprotection and neuromodulation

Yanming Zuo, Jingjia Ye, Wanxiong Cai, Binjie Guo, Xiangfeng Chen, Lingmin Lin, Shuang Jin, Hanyu Zheng, Ao Fang, Xingran Qian, Zeinab Abdelrahman, Zhiping Wang, Zhipeng Zhang, Bin Yu, Xiaosong Gu, Xuhua Wang

This study develops a noninvasive nanodrug delivery system for spinal cord injury that targets both ROS scavenging and neuronal excitability, leading to significant functional recovery in rats.

bioRxiv · Feb 14, 2022 · PreprintNeuroscience