Xuhua Wang

Mapping AAV capsid sequences to functions through function-guided in silico evolution

The paper introduces ALICE, a platform that uses function-guided in silico evolution to design AAV capsids with tailored properties, demonstrating improved targeting and tropism in mice.

Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy

This paper introduces FeatNN, a coevolutionary strategy for predicting compound-protein binding affinity by jointly representing protein sequence and structure information, achieving higher accuracy than existing methods.

Single cell sequencing reveals microglia induced angiogenesis by specific subsets of endothelial cells following spinal cord injury

This study uses scRNA-seq to identify immune cell-driven angiogenesis mechanisms in rat spinal cord injury.

Improving functional recovery after severe spinal cord injury by a noninvasive dual functional approach of neuroprotection and neuromodulation

This study develops a noninvasive nanodrug delivery system for spinal cord injury that targets both ROS scavenging and neuronal excitability, leading to significant functional recovery in rats.