Author

Linya You

Shanghai Medical College of Fudan UniversityORCID 0000-0002-2569-0269Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:database / resource· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Organism:mouse· 1

Frequent Co-Authors

Andrew JiangiD· 2 shared Klaus LehnertiD· 2 shared Russell G. SnelliD· 2 shared Christopher Simon BawdeniD· 1 shared Clive J. McLaughlan· 1 shared Guomin ZhouiD· 1 shared Guoxiang WangiD· 1 shared Henry John WaldvogeliD· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Andrew JiangORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 20, 2023

Evidence for glutamate excitotoxicity that occurs before the onset of striatal cell loss and motor symptoms in an ovine Huntington's Disease model.

Andrew Jiang, Linya You, Renée R. Handley…·Russell G. Snell

The paper identifies transcriptional upregulation of glutamate receptors and downregulation of oxidative phosphorylation in an ovine HD model before neuronal loss and motor symptoms.

1 citation

bulk RNA-seqstatistical model

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJan 23, 2023

Delineation of complex gene expression patterns in single cell RNA-seq data with ICARUS v2.0

Andrew Jiang, Linya You, Russell G. Snell, Klaus Lehnert

ICARUS v2.0 provides a web-based tool for analyzing single cell RNA-seq data with features for gene network analysis, trajectory inference, cell communication, and GWAS integration.

3 citations

scRNA-seqstatistical model

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NeuroscienceG3 Genes Genomes GeneticsPeer-reviewedMar 21, 2021

Deficiency of intellectual disability-related gene Brpf1 reduced inhibitory neurotransmission and Map2k7 expression in GABAergic interneurons

Jingli Cao, Weiwei Xian, Maierdan Palihati…·Linya You

This study shows that Brpf1 deficiency in GABAergic interneurons reduces inhibitory neurotransmission and alters Map2k7 expression.

7 citations

mousebulk RNA-seq

𝕏 PostBluesky