Author

Clive J. McLaughlan

South Australian Research and Development Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Andrew JiangiD· 2 shared Christopher Simon BawdeniD· 2 shared Jessie C. JacobseniD· 2 shared Klaus LehnertiD· 2 shared Paul John VermaiD· 2 shared Renée R. HandleyiD· 2 shared Russell G. SnelliD· 2 shared Suzanne J. ReidiD· 2 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Andrew JiangORCID

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Author profile →

2 papers

Recent·Most cited

Evidence for glutamate excitotoxicity that occurs before the onset of striatal cell loss and motor symptoms in an ovine Huntington's Disease model.

Andrew Jiang, Linya You, Renée R. Handley, Victoria Hawkins, Suzanne J. Reid, Jessie C. Jacobsen, Stefano Patassini, Skye R. Rudiger, Clive J. McLaughlan, Jennifer M. Kelly, Paul John Verma, Christopher Simon Bawden, James F. Gusella, Marcy E. MacDonald, Henry John Waldvogel, , Russell G. Snell

The paper identifies transcriptional upregulation of glutamate receptors and downregulation of oxidative phosphorylation in an ovine HD model before neuronal loss and motor symptoms.

bioRxiv · Jun 20, 2023 · PreprintNeuroscience

Isolated nuclei from frozen tissue are the superior source for single cell RNA-seq compared with whole cells.

Andrew Jiang, Klaus Lehnert, Suzanne J. Reid, Renée R. Handley, Jessie C. Jacobsen, Syke R. Rudiger, Clive J. McLaughlan, Paul John Verma, Christopher Simon Bawden, Russell G. Snell

This study compares single cell RNA-seq data from frozen tissue cells and nuclei, finding nuclei provide higher quality data with more gene and UMI counts and better clustering resolution.

bioRxiv · Feb 19, 2023 · PreprintGenomics