Author

Renée R. Handley

University of AucklandORCID 0000-0001-7935-2399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Russell G. SnelliD· 3 shared Andrew JiangiD· 2 shared Christopher Simon BawdeniD· 2 shared Clive J. McLaughlan· 2 shared Jessie C. JacobseniD· 2 shared Klaus LehnertiD· 2 shared Paul John VermaiD· 2 shared Suzanne J. ReidiD· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Russell G. SnellORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 20, 2023

Evidence for glutamate excitotoxicity that occurs before the onset of striatal cell loss and motor symptoms in an ovine Huntington's Disease model.

Andrew Jiang, Linya You, Renée R. Handley…·Russell G. Snell

The paper identifies transcriptional upregulation of glutamate receptors and downregulation of oxidative phosphorylation in an ovine HD model before neuronal loss and motor symptoms.

1 citation

bulk RNA-seqstatistical model

𝕏 PostBluesky

GenomicsbioRxivPreprintFeb 19, 2023

Isolated nuclei from frozen tissue are the superior source for single cell RNA-seq compared with whole cells.

Andrew Jiang, Klaus Lehnert, Suzanne J. Reid…·Russell G. Snell

This study compares single cell RNA-seq data from frozen tissue cells and nuclei, finding nuclei provide higher quality data with more gene and UMI counts and better clustering resolution.

5 citations

humanscRNA-seq

𝕏 PostBluesky

Molecular BiologyBMC GenomicsPeer-reviewedAug 26, 2020

A new mechanism for a familiar mutation - bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement

Tania Fink, Thomas Lopdell, Kathryn Tiplady…·Mathew D. Littlejohn

The paper re-examines the mechanism of the DGAT1 K232A mutation in bovine milk production, showing it modulates gene expression through splicing enhancement.

29 citations

bulk RNA-seqstatistical model

𝕏 PostBluesky