Author

Jun Zhou

University of MichiganORCID 0000-0002-2576-7692Unclaimed ORCID profile · follow to get notified of new preprints

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Jun Zhou8 papers · Center for Life Sciences

Biology Disciplines

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Bioinformatics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:protein design· 2 Research Focus:software / tool· 2 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Assay:protein sequence· 1

Frequent Co-Authors

Jie XuiD· 3 shared Xiaofeng XiaiD· 3 shared Xiaoqiang HuangiD· 3 shared Y. Eugene CheniD· 3 shared Shuang CheniD· 2 shared Dongshan YangiD· 1 shared Jifeng Zhang· 1 shared Jifeng ZhangiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBioinformatics

Jie XuORCID

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3 papers

Recent·Most cited

Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability using UniDesign

Youcai Xiong, Li-Kuang Tsai, Jun Zhou, Shuang Chen, Xiaofeng Xia, Jifeng Zhang, Y. Eugene Chen, Jie Xu, Xiaoqiang Huang

This paper computationally designs a PAM-relaxed SaCas9 variant, KRH, with expanded targeting capability and enhanced editing efficiency.

eLife · Apr 24, 2026Peer-reviewedBioengineering

Fast, accurate parsing of antibody structures and antibody-antigen interactions enables a comprehensive structural antibody database

Xiaoqiang Huang, Jun Zhou, Shuang Chen, Xiaofeng Xia, Y. Eugene Chen, Jie Xu

The paper introduces SAAINT-parser, a tool for extracting antibody and antibody-antigen interaction data from PDB, resulting in SAAINT-DB, which offers more accurate and comprehensive data than existing databases.

Acta Pharmacologica Sinica · Jun 30, 2025Peer-reviewedBioinformatics

Decoding CRISPR-Cas9 PAM recognition with UniDesign

Xiaoqiang Huang, Jun Zhou, Dongshan Yang, Jifeng Zhang, Xiaofeng Xia, Y. Eugene Chen, Jie Xu

The paper introduces UniDesign, a computational framework for designing protein-nucleic acid interactions, and demonstrates its ability to accurately predict PAM-PIAA interactions for Cas9 proteins.

Briefings in Bioinformatics · Mar 16, 2023Peer-reviewedBioinformatics