Jie Xu

This paper computationally designs a PAM-relaxed SaCas9 variant, KRH, with expanded targeting capability and enhanced editing efficiency.

The paper introduces SAAINT-parser, a tool for extracting antibody and antibody-antigen interaction data from PDB, resulting in SAAINT-DB, which offers more accurate and comprehensive data than existing databases.

The paper introduces UniDesign, a computational framework for designing protein-nucleic acid interactions, and demonstrates its ability to accurately predict PAM-PIAA interactions for Cas9 proteins.

This study creates a rabbit model with USH2A mutations causing hearing loss and progressive retinal degeneration, mimicking human Usher Syndrome.

The paper characterizes the diversity and evolution of the Msg gene superfamily across Pneumocystis species, revealing its functional roles in immune evasion and host adaptation.