Y. Eugene Chen

This study shows that RyR2-mediated Ca2+ leak causes arrhythmias and progressive cardiomyopathy in rabbits, identifying RyR2 as a therapeutic target.

The paper develops a serum-free 6iL/E4 culture system that enables derivation and maintenance of embryonic stem cells (ESCs) across multiple mammalian species, revealing conserved mechanisms for ESC self-renewal.

This paper computationally designs a PAM-relaxed SaCas9 variant, KRH, with expanded targeting capability and enhanced editing efficiency.

This paper designs CYP102A1 variants to biosynthesize the antiplatelet drug DT-678, showing improved catalytic activity and productivity with ascorbic acid protection.

The paper introduces SAAINT-parser, a tool for extracting antibody and antibody-antigen interaction data from PDB, resulting in SAAINT-DB, which offers more accurate and comprehensive data than existing databases.

This paper introduces a method to degrade phospho-14-3-3-binding-motif proteins using a ubiquitin-proteasome system, demonstrating its efficiency and specificity for studying these proteins.

The paper introduces UniDesign, a computational framework for designing protein-nucleic acid interactions, and demonstrates its ability to accurately predict PAM-PIAA interactions for Cas9 proteins.

This study creates a rabbit model with USH2A mutations causing hearing loss and progressive retinal degeneration, mimicking human Usher Syndrome.

This study identifies 144 genetic loci associated with abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target through Mendelian Randomization and pre-clinical validation.

This study shows that ASC exosomes alleviate myocardial infarction by delivering miR-31, which targets FIH1 and activates HIF-1α to promote angiogenesis.

The paper identifies loss-of-function variants affecting liver-related blood traits that reduce CVD risk without increasing metabolic disease risk, highlighting potential therapeutic targets.