Jifeng Zhang

Ignet 2.0 and Vignet provide ontology-driven platforms for gene interaction discovery, vaccine network analysis, and AI-assisted knowledge retrieval from biomedical literature.

This paper designs CYP102A1 variants to biosynthesize the antiplatelet drug DT-678, showing improved catalytic activity and productivity with ascorbic acid protection.

The paper introduces UniDesign, a computational framework for designing protein-nucleic acid interactions, and demonstrates its ability to accurately predict PAM-PIAA interactions for Cas9 proteins.

This study creates a rabbit model with USH2A mutations causing hearing loss and progressive retinal degeneration, mimicking human Usher Syndrome.

This study identifies 144 genetic loci associated with abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target through Mendelian Randomization and pre-clinical validation.

The paper identifies loss-of-function variants affecting liver-related blood traits that reduce CVD risk without increasing metabolic disease risk, highlighting potential therapeutic targets.