Structural divergence in N-terminal domains of AAA proteases paraplegin (SPG7) and FtsH indicates a key structural function in complex formation
James G. Hyatt, Neil G. Paterson, Juliette M. Devos, Cristiano Oliveira, christian M. Jessen, Sylvain François Prévost, Andreas Hofmann, Jan Skov Pedersen, Anja Winter
This study compares the structural properties of the N-terminal domains of human paraplegin (SPG7) and bacterial FtsH, revealing differences in oligomerization and domain-swapping that may contribute to AAA protease function and disease.
Journal of Structural Biology · Aug 3, 2026Peer-reviewedBiochemistry