Jan Skov Pedersen

This study compares the structural properties of the N-terminal domains of human paraplegin (SPG7) and bacterial FtsH, revealing differences in oligomerization and domain-swapping that may contribute to AAA protease function and disease.

This study presents multi-domain OGA structures from Trichoplax adhaerens and human, revealing allosteric regulatory mechanisms involving the pHAT domain.

This study investigates how myelin proteins P0, MBP, and P2 interact with lipid membranes and each other, revealing both synergistic and competitive effects on membrane structure and stability.

The paper identifies rare missense variants in LAR that destabilize the extracellular domain, disrupt LAR:NGL-3 interactions, and impair synaptic adhesion and synaptogenesis.