Yves Heremans

This study demonstrates that liver-directed AAV gene therapy corrects metabolic defects in Hgd-deficient mice by restoring HGD expression and reducing HGA levels without hypertyrosinemia.

This study shows that gut insulin receptor loss increases intestinal permeability and susceptibility to infections by impairing Paneth cell function and intestinal stem cell homeostasis.

The paper shows that ER stress relief in beta cells promotes proliferation, independent of vascular recovery, by using transgene overexpression and chemical induction.