The gut insulin receptor acts as gatekeeper of intestinal barrier integrity
Florian Sicherre, Dalale Gueddouri, Michèle Caüzac, Adele Caudron-Hedeline, Fadila Benhamed, Wafa Charifi, Benoît Terris, Benoît Chassaing, Lucie Beaudoin, Matthieu Rouland, Angela Bosh, Claudia Cavelti‐Weder, Gunter Leuckx, Yves Heremans, Agnès Lehuen, , Sandra Guilmeau
This study shows that gut insulin receptor loss increases intestinal permeability and susceptibility to infections by impairing Paneth cell function and intestinal stem cell homeostasis.
bioRxiv · Sep 29, 2025 · PreprintPhysiology