Daniel Hesselson

Examining Selection Dynamics and Limitations in Multi-round Protein Selection of High Diversity Libraries

The paper presents analyses to assess selection dynamics in multi-round protein selection experiments, offering insights into diversity, coverage, and reproducibility.

A chimeric viral platform for directed evolution in mammalian cells

This paper introduces PROTEUS, a chimeric viral platform for directed evolution in mammalian cells, demonstrating its ability to generate sensitive gene regulation tools and DNA damage-responsive nanobodies.

Characterization of cell-cell communication in COVID-19 patients

The paper characterizes cell-cell communication patterns in COVID-19 patients to identify differences between moderate and severe disease outcomes using single-cell RNA-seq data.

"Cheater" particles render the VEGAS platform unsuitable for mammalian directedevolution

The paper shows the VEGAS platform for mammalian directed evolution is ineffective due to cheater particles that outcompete transgenes and prevent directed evolution.

Developmental accumulation of gene body and transposon non-CpG methylation in the zebrafish brain

This study identifies mCH accumulation at CAC trinucleotides in zebrafish brain development and shows Dnmt3a's role in mCAC deposition, demonstrating evolutionary conservation of mCH dynamics.

A zebrafish functional genomics model to investigate the role of human A20 variants in vivo

This paper uses a zebrafish model to study the in vivo effects of human A20 variants, showing that specific mutations impact A20 function and disease relevance.