Central infusion of prostaglandin E2 reveals a unified representation of sickness in the mouse insular cortex
Gretel B. Kamm, Juan Carlos Boffi, Muad Y Abd El Hay, Domitille Rajot, Ana Cukić, Martha Nari Havenith, Marieke Louise Schölvinck, Nicolas Renier, Hiroki Asari, Robert Prevedel
This study shows that PGE2 induces a sickness-like state in mice, with the insular cortex encoding integrated sickness signals better than the somatosensory cortex.
Current Biology · Sep 30, 2026Peer-reviewedNeuroscience