Jan Siemens

This paper introduces a mobile optical coherence microscope for high-resolution, label-free imaging of aquatic organisms in both lab and field settings, enabling detailed morphological and dynamic analysis.

The paper identifies POAVglut2 neurons in the preoptic area as critical for capsaicin-induced hypothermia by selectively silencing neuronal subtypes and assessing their contribution to the hypothermic response.

This study investigates the distinct roles of TRPV1 and TRPM2 in warm-temperature detection using cultured mouse DRG neurons and behavioral assays, revealing their unique contributions to thermal perception and decision-making.

The paper identifies hypothalamic preoptic neurons that develop warm-sensitive activity during heat acclimation, enabling heat tolerance through cell-autonomous mechanisms.

This study identifies two hypothalamic pathways that regulate body temperature and feeding, with one pathway uniquely suppressing food intake and promoting tail vasodilation in hot environments.

This study shows that spinal astrocytic glycogen dynamics, regulated by PTG, are critical for maintaining persistent pain through neuronal plasticity and metabolic coupling with neurons.

This study shows that oxytocin acts on astrocytes in the central amygdala to promote a positive emotional state, challenging the notion that oxytocin only affects neurons.

The paper generates hESC-derived nociceptor-like cells and shows they exhibit mechano-nociceptive characteristics requiring PIEZO2 for mechanotransduction.