Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue
Aamir S. Mukadam, Lauren V. C. Miller, Claire S. Durrant, Marina J. Vaysburd, Taxiarchis Katsinelos, Benjamin J. Tuck, Sophie Sanford, Olivia Sheppard, Claire Knox, Shi Cheng, Leo C. James, Michael P. Coleman, William A. McEwan
The paper investigates whether tau assemblies behave like independently acting prion-like particles in mouse neural tissue and finds that seeding behavior only occurs at supra-physiological concentrations.
Acta Neuropathologica Communications · Mar 12, 2021Peer-reviewedNeuroscience