Yang Xiang

This study uses mitochondrial variants as barcodes to track clonal dynamics and spatial organization in human hematopoietic organoids.

The paper identifies hypoblasts as the origin of the first blood cells in human and non-human primate embryos, showing they contribute to hemoglobin+ phagocyte-like cells and sustain oxygen levels before heart formation.

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

The paper defines the single-cell spatiotemporal gene expression landscape of human embryonic development using stem-cell-derived organoids and identifies key developmental signatures and signaling pathways.