Pentao Liu

The paper identifies hypoblasts as the origin of the first blood cells in human and non-human primate embryos, showing they contribute to hemoglobin+ phagocyte-like cells and sustain oxygen levels before heart formation.

This study identifies KIF27 as a key regulator of motile cilia assembly by maintaining transition-zone integrity, revealing its role in ciliary structure and function across species.

This paper introduces inDecay, a few-shot learning system for predicting CRISPR editing outcomes in cell lines and zygotes, achieving high accuracy with minimal data.

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

This study identifies a Bcl11b/C1ql2/Nrxn3(25b+) pathway that regulates mossy fiber-CA3 synapse function through C1ql2's interaction with Nrxn3(25b+).

The paper defines the single-cell spatiotemporal gene expression landscape of human embryonic development using stem-cell-derived organoids and identifies key developmental signatures and signaling pathways.

SpatialDM identifies spatially co-expressed ligand-receptor pairs and communication patterns in spatial transcriptomics data with high accuracy and scalability.

This paper generates a Bcl11a lineage tracing mouse model to track Bcl11a-expressing cells in vivo and validates it in the mammary gland.

This study identifies BCL11A as a defining transcription factor for a distinct subset of midbrain dopamine neurons, showing their vulnerability to Parkinson's disease and developmental roles in motor function.

This paper corrects FKRP mutations in iPSCs using CRISPR/Cas9, restoring functional glycosylation of α-dystroglycan in cortical neurons and validating the role of FKRP in dystroglycanopathies.

The paper shows that a TALE-based repressor targeting Xist intron 1 enhances iPSC generation and SCNT embryo development in mice, without affecting Xist expression.

This paper establishes expanded potential stem cells (EPSCs) from mouse blastomeres and shows they can contribute to both embryo proper and trophoblasts in chimeras.