Ryohichi Sugimura

This study uses mitochondrial variants as barcodes to track clonal dynamics and spatial organization in human hematopoietic organoids.

The paper identifies hypoblasts as the origin of the first blood cells in human and non-human primate embryos, showing they contribute to hemoglobin+ phagocyte-like cells and sustain oxygen levels before heart formation.

This paper develops a degradable hydrogel for in vivo tumor modeling that supports vascularization and immune cell therapy testing in mice.

This paper develops an injectable hydrogel with antibacterial properties for tissue engineering applications, showing good biocompatibility and ability to form 3D cell aggregates.

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

SpatialScope integrates spatial and single-cell transcriptomics data using deep generative models to achieve single-cell resolution and infer transcriptome-wide expression levels.

The paper defines the single-cell spatiotemporal gene expression landscape of human embryonic development using stem-cell-derived organoids and identifies key developmental signatures and signaling pathways.

This study identifies that HUVECs amplify erythroid cells through secreted angiocrine factors by maintaining their undifferentiated state and activating ERK signaling.