This study validates the adhesion-clutch mechanism in 3D environments by showing that N-cadherin and shootin1a drive axon outgrowth when present in an appropriate adhesive substrate.

bioRxiv · Sep 10, 2026 · PreprintNeuroscience

Mechanical polarity links adhesion-tuned protrusions to directional stability in glioblastoma cell migration

Haruna Tagawa, Daisuke Kanematsu, Asako Katsuma, Naoyuki Inagaki, Yonehiro Kanemura, Yuichi Sakumura

The paper establishes mechanical polarity as a physical principle linking adhesion dynamics to directional stability in glioblastoma cell migration.

bioRxiv · Oct 23, 2025 · PreprintSystems Biology

Weak and tunable adhesion-clutch drives rapid cell migration and glioblastoma motility

Kentarou Baba, Ami Fukushi-Kumagaya, Megumi Morisaki, Ryosuke F. Takeuchi, Zhijie Xiao, Yoshikazu Nagashima, Mizuki Sakai, Yasuna Higashiguchi, Hiroko Katsuno‐Kambe, Asako Katsuma, Yoshihiro Ueda, Yuji Kamioka, Daisuke Kawauchi, Tatsuo Kinashi, Yonehiro Kanemura, Naoyuki Inagaki

The paper identifies a weak, integrin-independent adhesion-clutch mechanism involving shootin1 and L1 that enables rapid cell migration and glioblastoma motility by transmitting weak traction forces.

bioRxiv · Jan 13, 2025 · PreprintCell Biology