Author

Hassan Hosseini

University of MichiganORCID 0000-0002-2702-6994Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:cell type annotation· 5 Assay:electronic health records· 5 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Kevin S. JonesiD· 4 shared Matthias PriggeiD· 2 shared Sky Evans-Martin· 2 shared Adejimi Aromolaran· 1 shared Amir Mohammad RahimiiD· 1 shared David Hernandez‐Pineda· 1 shared Dominique L. PritchettiD· 1 shared Emma Bogomilsky· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersNeuroscience

Kevin S. JonesORCID

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Author profile →

7 papers

Recent·Most cited

Chronic nicotine reduces nigral dopaminergic activity and remodels pedunculopontine cholinergic subpopulations

Rita Yu-Tzu Chen, Hassan Hosseini, Skylar Hall, S. Zhang, Rebekah C. Evans

This study examines how chronic nicotine affects dopaminergic neurons in the substantia nigra and cholinergic neurons in the pedunculopontine nucleus, revealing changes in their activity and morphology that may contribute to Parkinson's disease resilience.

bioRxiv · Feb 14, 2026 · PreprintNeuroscience

Grin2a Dysfunction Impairs Cognitive Flexibility by Disrupting LC Modulation of mPFC Circuits

Hassan Hosseini, Sky Evans-Martin, Emma Bogomilsky, Kevin S. Jones

This study shows that Grin2a mutations impair cognitive flexibility by disrupting locus coeruleus modulation of mPFC circuits and noradrenergic signaling.

bioRxiv · Feb 1, 2025 · PreprintNeuroscience

Grin2a Ablation Distinctly Reshapes PV+ and SST+ Interneuron circuits in the Medial Prefrontal Cortex to Amplify Gamma Oscillations

Hassan Hosseini, Sky Evans-Martin, Kevin S. Jones

This study investigates how Grin2a ablation affects inhibitory interneurons in the mPFC, revealing changes in synaptic transmission and gamma oscillations linked to schizophrenia risk.

bioRxiv · Dec 23, 2024 · PreprintNeuroscience

Grin2a Hypofunction Disrupts Hippocampal Network Oscillations and E/I Balance Contributing to Cognitive Deficits

Hassan Hosseini, Jean C. Rodríguez Díaz, Dominique L. Pritchett, Morgan Sheng, Kevin S. Jones

This study shows that Grin2a mutations impair spatial working memory and disrupt hippocampal network oscillations and E/I balance.

bioRxiv · Nov 9, 2024 · PreprintNeuroscience

Molecular diversity and connectivity of accessory olfactory system neurons

Nandkishore Prakash, Heidi Y. Matos, Sonia Sebaoui, Luke Tsai, Tuyen Tran, Adejimi Aromolaran, Isabella Atrachji, Nya Campbell, Meredith Goodrich, David Hernandez‐Pineda, María Jesús Herrero, Tsutomu Hirata, Julieta E. Lischinsky, Wendolin Martinez, Shisui Torii, , Joshua G. Corbin

The paper investigates molecular diversity and connectivity patterns in accessory olfactory system neurons, revealing lineage- and sex-specific differences in connectivity.

The Journal of Comparative Neurology · Oct 17, 2023Peer-reviewedNeuroscience

A versatile Synaptotagmin-1 nanobody provides perturbation-free live synaptic imaging and low linkage-error in super-resolution microscopy

Karine Queiroz Zetune Villa Real, Nikolaos Mougios, Ronja Rehm, Shama Sograte‐Idrissi, László Albert, Amir Mohammad Rahimi, Manuel Maidorn, Jannik Hentze, Markel Martínez‐Carranza, Hassan Hosseini, Kim‐Ann Saal, Nazar Oleksiievets, Matthias Prigge, Roman Tsukanov, Pål Stenmark, , Felipe Opazo

This paper introduces a nanobody that enables non-invasive live synaptic imaging and improves super-resolution microscopy with minimal physiological impact.

Small Methods · Jul 8, 2023Peer-reviewedNeuroscience

Spike-dependent dynamic partitioning of the Locus coeruleus network through noradrenergic volume release in a simulation of nucleus core

Shristi Baral, Hassan Hosseini, Kaushik More, Thomaz Mansini Carrenho Fabrin, Jochen Braun, Matthias Prigge

The paper simulates the Locus coeruleus network to show that noradrenergic volume release mediates spike-dependent dynamic partitioning through alpha2-receptor interactions.

Brain Sciences · Jun 1, 2022Peer-reviewedNeuroscience