Morgan Sheng

Discovery of GluA3 preferring AMPA receptor positive allosteric modulator BRD3290

This study discovers BRD3290, a GluA3-preferring AMPA receptor PAM, but finds it does not improve cognitive function in mice despite target engagement.

Comparative analysis of microglia-targeted AAVs reveals capsid choice drives efficiency in vitro but has limited impact in vivo

The paper compares microglia-targeted AAVs, finding that capsid choice affects in vitro efficiency but not in vivo transduction when using specific promoters.

Rescue schizophrenia-related phenotypes caused by Setd1a deficiency by histone demethylase inhibitors

This study identifies TAK-418 as a histone demethylase inhibitor that rescues schizophrenia-like phenotypes in Setd1a-deficient mice by restoring H3K4me3 levels and gene expression.

Spatially resolved translational dysregulation in Grin2a+/- mouse model of schizophrenia

The paper uses spatial omics to analyze translational dysregulation in Grin2a+/- mice, finding gene-specific translation reductions in neurons and non-neuronal cells linked to schizophrenia pathophysiology.

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

The G-protein coupled receptor GPR34 maintains the homeostatic state of microglia and restrains the disease-associated microglial response in an Alzheimers disease model

This study shows that GPR34 maintains microglial homeostasis and limits disease-associated microglial responses in Alzheimer's disease models.

Altered striatal dopamine dynamics and behavior in Grin2a mutant mice, a genetic mouse model of schizophrenia

This study examines the effects of Grin2a and Akap11 mutations on striatal dopamine dynamics and behavior in mice, revealing distinct impacts on locomotion and neural activity.

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus

This study performs a meta-analysis of brain transcriptomes from genetic mouse models of schizophrenia, identifying dysregulation in striatum and thalamus with distinct patterns in different models.

Abnormal Lipid Metabolism and Altered Neuronal Support by Astrocytes Lacking Akap11, a Risk Gene for Schizophrenia and Bipolar Disorder

This study identifies AKAP11's role in regulating lipid metabolism and neuronal support in astrocytes, linking its dysfunction to schizophrenia and bipolar disorder risk.

Epigenetic changes, neuronal dysregulation and metabolomic abnormalities in Zmym2 mutant mice, a genetic model of schizophrenia and neurodevelopmental disorders

Brain-region-specific changes and dysregulation of activity regulated genes in Gria3 mutant mice, a genetic animal model of schizophrenia

This study examines Gria3 mutant mice to identify transcriptomic and proteomic changes linked to schizophrenia, finding region-specific gene dysregulation and synaptic protein alterations.

Grin2a Hypofunction Disrupts Hippocampal Network Oscillations and E/I Balance Contributing to Cognitive Deficits

This study shows that Grin2a mutations impair spatial working memory and disrupt hippocampal network oscillations and E/I balance.

Multimodal synaptomics reveals coordinated synaptic activity, protein synthesis and reorganization in NMDAR regulation

This paper uses multimodal synaptomics to study how ketamine-induced changes in synaptic proteins and activity relate to schizophrenia models.

Muti-omics characterization reveals brain-wide disruption of synapses and region- and age-specific changes in neurons and glia in Sp4 mutant mice, a genetic model of schizophrenia and bipolar disorder

This study uses multi-omics analyses of Sp4 mutant mice to reveal synapse disruption and age- and region-specific neuronal and glial changes linked to schizophrenia and bipolar disorder.

SRRM2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a mouse model of schizophrenia

This study shows that SRRM2 haploinsufficiency in mice causes synaptic, splicing, and myelination defects linked to schizophrenia-like behaviors and gene expression changes.

Differential Functional Consequences of GRIN2A Mutations Associated with Schizophrenia and Neurodevelopmental Disorders

This study investigates how different GRIN2A mutations linked to schizophrenia, epilepsy, and developmental disorders affect NMDA receptor function, revealing distinct functional consequences.

TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

This study shows that TPL2 kinase activity in microglia drives neuroinflammation and neurodegeneration in tauopathy models, suggesting it as a therapeutic target.

Btbd11 is an inhibitory interneuron specific synaptic scaffolding protein that supports excitatory synapse structure and function

This study identifies Btbd11 as an inhibitory interneuron-specific protein that supports glutamatergic synapse structure and function, with implications for neural circuitry and behavior.

Deep proteomics identifies shared molecular pathway alterations in synapses of schizophrenia and bipolar disorder patients and mouse model

Neuronal pentraxin Nptx2 regulates complement activity in the brain

This study identifies Nptx2 as a regulator of complement activity in the brain, showing its role in preventing microglial synapse elimination in health and disease.

Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in an Alzheimer's disease model

The paper introduces STARmap PLUS to map single-cell transcriptional states and disease markers in AD mouse models, revealing spatial relationships between cell types and pathological features.

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice

This study identifies brain region-specific changes and dopamine dysregulation in Grin2a mutant mice, supporting schizophrenia hypotheses and highlighting their utility as a genetic model.

Perturbations of a causal synaptic molecular network in autism and schizophrenia revealed with multiplexed imaging

The paper uses PRISM to analyze how knocking down 16 autism and schizophrenia genes affects synaptic protein distributions and constructs a causal network model.

Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients

This study examines EEG abnormalities in Grin2a and Akap11 mutant mice, finding similarities with schizophrenia patients, suggesting these mutants as models for the disorder.